Selected Publications

Henderson BW, Greathouse KM, Ramdas R, Walker CK, Rao TC, Bach SV, Curtis KA, Day JJ, Mattheyses AL, Herskowitz JH. (2019) Pharmacologic inhibition of LIMK1 provides dendritic spine resilience against amyloid-β. Science Signaling.
Article highlighted by Cover Graphic.
Article highlighted by Drug Target Review
Article highlighted by GEN News
Article highlighted by Medical Express
Article highlighted by News Medical
Article highlighted by InfoSalus
Article highlighted by EurekAlert!
Article highlighted by FOX6 WBRC
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Greathouse KM, Henderson BW, Gentry EG, Herskowitz JH. (2019) Fasudil or genetic depletion of ROCK1 or ROCK2 induces anxiety-like behaviors. Behavioural Brain Research.
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Vo HT, Phillips ML, Herskowitz JH, King GD
. (2019) Klotho deficiency promotes neuronal spine remodeling and network synchronization. Molecular and Cellular Neuroscience.
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Boros BD, Greathouse KM, Gearing M, Herskowitz JH. (2019) Dendritic spine remodeling accompanies Alzheimer’s disease pathology and genetic susceptibility in cognitively normal aging. Neurobiology of Aging.
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Greathouse KM, Boros BD, Deslauriers JF, Henderson BW, Curtis KA, Gentry EG, Herskowitz JH
. (2018) Distinct and Complementary Functions of Rho kinase isoforms ROCK1 and ROCK2 in Prefrontal Cortex Structural Plasticity. Brain Structure and Function.
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Froula JM, Henderson BW, Gonzalez JC, Vaden JH, Mclean JW, Wu Y, Banumurthy G, Overstreet-Wadiche L, Herskowitz JH, Volpicelli-Daley LA
. (2018) α-Synuclein fibril-induced paradoxical structural and functional defects in hippocampal neurons. Acta Neuropathologica Communications.
Article highlighted by Neuroscience News & Research
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Boros BD, Greathouse KM, Gentry EG, Curtis KA, Birchall EL, Gearing M, Herskowitz JH. (2017) Dendritic spines provide cognitive resilience against Alzheimer’s disease. Annals of Neurology
Article highlighted by Neurology Today
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Article highlighted by New Scientist
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Henderson BW, Gentry EG, Rush, T, Troncoso JC, Thambisetty M, Montine TJ, Herskowitz JH. (2016) Rho-associated protein kinase 1 (ROCK1) is increased in Alzheimer's disease and ROCK1 depletion reduces amyloid-β levels in brain. Journal of Neurochemistry.
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Gentry EG, Henderson BW, Arrant, AE, Gearing M, Feng Y, Riddle NC, Herskowitz JH. (2016) Rho Kinase Inhibition as a Therapeutic for Progressive Supranuclear Palsy and Corticobasal Degeneration.  Journal of Neuroscience
Article highlighted by ALZFORUM News.
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Swanger SA, Mattheyses AL, Gentry EG, Herskowitz JH. (2015) ROCK1 and ROCK2 inhibition alters dendritic spine morphology in hippocampal neurons. Cellular Logistics.
Article highlighted by Cover Graphic.
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Herskowitz JH, Feng Y, Mattheyses AL, Hales CM, Higginbotham LA, Duong DM, Montine TJ, Troncoso JC, Thambisetty M, Seyfried NT, Levey AI, Lah JJ. (2013) Pharmacologic inhibition of ROCK2 suppresses amyloid-β production in an Alzheimer disease mouse model. Journal of Neuroscience.
Editor’s Featured Article.
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Pranski EL, Van Sanford C, Dalal NV, Herskowitz JH, Gearing M, Lazo C, Miller GW, Lah JJ, Levey AI, Betarbet RS. (2013) RING finger protein 11 (RNF11) modulates susceptibility to 6-OHDA-induced nigral degeneration and behavioral deficits through NF-kB signaling in dopaminergic cells. Neurobiology of Disease.
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Sager KL, Wuu J, Herskowitz JH, Mufson EJ, Levey AI, Lah JJ. (2012) Neuronal LR11 expression does not differentiate between clinically-defined Alzheimer’s disease and control brains. PLOS ONE.
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Herskowitz JH, Gozal YM, Duong DM, Dammer EB, Gearing M, Ye K, Lah JJ, Peng J, Levey AI, Seyfried NT. (2012) Asparaginyl endopeptidase cleaves TDP-43 in brain. Proteomics.
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Herskowitz JH, Offe K, Deshpande A, Kahn RA, Levey AI, Lah JJ. (2012) GGA1-mediated endocytic traffic of LR11/SorLA alters APP intracellular distribution and amyloid-β production. Molecular Biology of the Cell.
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Pranski EL, Dalal NV, Herskowitz JH, Orr AL, Roesch LA, Fritz JJ, Heilman C, Lah JJ, Levey AI, Betarbet RS. (2012) Neuronal RING Finger Protein 11 (RNF11) regulates canonical NF-κB signaling. Journal of Neuroinflammation.
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Seyfried NT, Gozal YM, Donovan LE, Herskowitz JH, Dammer EB, Xia Q, Ku L, Chang J, Duong DM, Rees H, Cooper DS, Glass JD, Gearing M, Tansey MG, Lah JJ, Feng Y, Levey AI, Peng J. (2012) Quantitative analysis of the detergent-insoluble brain proteome in frontotemporal lobar degeneration using SILAC internal standards. Journal of Proteome Research (ACS).
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Herskowitz JH, Seyfried NT, Gearing M, Kahn RA, Peng J, Levey AI, Lah JJ. (2011) Rho kinase II phosphorylation of the lipoprotein receptor LR11/SorLa alters amyloid-β production. Journal of Biological Chemistry.
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Herskowitz JH, Seyfried NT, Duong DM, Xia Q, Rees HD, Gearing M, Peng J, Lah JJ, Levey AI. (2010) Phosphoproteomic analysis reveals site-specific changes in GFAP and NDRG2 phosphorylation in frontotemporal lobar degeneration. Journal of Proteome Research (ACS).
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